講座名稱：有機(jī)光學(xué)探針在余暉成像和疾病監(jiān)測中的應(yīng)用

講座時間：2020-07-24 14:30

講座人：浦侃裔

講座地點(diǎn)：騰訊會議直播（ID：728 765 427）

講座人介紹：

浦侃裔，博士，現(xiàn)任新加坡南洋理工大學(xué)化學(xué)與生物醫(yī)學(xué)工程學(xué)院副教授（終生教職），工學(xué)院助理部長，web of science高被引學(xué)者。本科、碩士畢業(yè)于華東理工大學(xué)和復(fù)旦大學(xué)；2011年于新加坡國立大學(xué)獲得博士學(xué)位，同年加入斯坦福大學(xué)醫(yī)學(xué)院從事博士后研究工作。研究興趣主要集中于基于有機(jī)半導(dǎo)體材料的生物光子學(xué)。已發(fā)表高水平SCI論文170多篇 （IF>10的112篇），著作3章，專利6項(xiàng)，H因子為69。獲得多項(xiàng)獎項(xiàng)，包括2020 Biomaterials Science Lectureship Award, 2019 highly cited researcher,日本化學(xué)會杰出報(bào)告獎、威利生物科學(xué)貢獻(xiàn)獎、青年學(xué)者旅游獎和納米生物技術(shù)青年創(chuàng)新獎等。浦教授擔(dān)任ACS Applied Polymer Materials 和Biomaterials Research副主編，Nano Research期刊Young Star主編，中美納米醫(yī)學(xué)與納米生物技術(shù)學(xué)會(CASNN)理事會成員，Advanced Functional Materials, Bioconjugate Chemistry, ACS Applied Bio Materials, Advanced Biosystems, Journal of Nanobiotechnology和ChemNanoMat等期刊編委。

講座內(nèi)容：

Optical imaging plays a crucial role in biology and medicine. However, the need for real-time light excitation during imaging produces tissue autofluorescence, and thus compromises imaging sensitivity and specificity. Meanwhile, optical agents are often retained in living bodies, posing additional toxicity issue. In this talk, I will introduce molecular afterglow reporters with long-lasting luminescence after removal of light excitation for ultrasensitive in vivo imaging, followed by discussion on how to design renal-clearable optical reporters for early diagnosis of kidney diseases. The in vivo afterglow of SPNs has the signal to background ratio more than two orders of magnitude higher than NIR fluorescence, enabling rapid detection of tiny peritoneal metastatic tumors. The structural diversity of SPNs allows them to monitor temperature during photothermal cancer therapy and detect biomarkers of interest in living mice. To detect acute kidney injury (AKI), molecular renal probes (MRPs) with high renal clearance efficiency are developed. MRPs specifically activate their NIR/chemiluminescence signals towards the prodromal biomarkers of AKI, enabling the first example of longitudinal imaging of multiple molecular events in the kidneys of living mice. MRPs also act as exogenous tracers for optical urinalysis that outperforms typical clinical/preclinical assays. These studies thus provide the basis for an entirely new class of molecular optical reporters with ultrahigh sensitivity and high translational potential for early diagnosis.

主辦單位：生命科學(xué)技術(shù)學(xué)院